Malignant hyperthermia testing in probands with NO adverse anesthetic reaction
نویسندگان
چکیده
Background Malignant hyperthermia (MH) is characterized by an adverse reaction to volatile anesthetic, and/or succinylcholine. Typically, following an adverse anesthetic reaction or positive family history, patients will undergo caffeine-halothane contracture (CHCT) and/ or genetic testing. However, sometimes patients with no individual or family history of anesthetic reaction are referred for MH testing due to a variety of reasons. The objective of our study was to investigate reasons for referrals in nonanesthetic cases, and assess their phenotype.
منابع مشابه
Malignant hyperthermia in Canada: characteristics of index anesthetics in 129 malignant hyperthermia susceptible probands.
BACKGROUND Between 1992 and 2011, 373 Canadian individuals with adverse anesthetic reaction were referred to the Malignant Hyperthermia Unit in Toronto, Ontario, Canada for malignant hyperthermia (MH) diagnostic testing. We analyzed the epidemiologic characteristics of the index adverse anesthetics for those probands who were confirmed to be MH susceptible. METHODS One hundred twenty-nine pro...
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BACKGROUND Malignant hyperthermia (MH) is triggered by reactions to anesthetics. Reports link nonanesthetic-induced MH-like reactions to a variety of disorders. The objective of the authors was to retrospectively investigate the reasons for referrals for MH testing in nonanesthetic cases and assess their phenotype. In addition, the response to the administration of oral dantrolene in nonanesthe...
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A 17 year old male who underwent surgery for thoracic outlet syndrome developed a postoperative complication which was labelled and diagnosed as malignant hyperthermia in Kerman Medical Center. The temperature recorded was 43°C, PaC02 70 mmHg and serum potassium level was 7 mEq/L. The patient was hospitalized in the intensive care unit for 10 days. On discharge, the patient had aphasia and...
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BACKGROUND Some patients develop recrudescence after a malignant hyperthermia (MH) reaction, but it is not clear which patients are at risk. The authors analyzed clinical variables associated with recrudescence after a clinical MH episode. METHODS Data were obtained from Adverse Metabolic Reaction to Anesthesia reports in the North American Malignant Hyperthermia Registry. Patients who underw...
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